Diagnosis and management of iatrogenic ureteral injury in total laparoscopic hysterectomy

Ureteral injury is common in gynecological surgeries due to the proximity to organs. The risk of ureteral injury is higher in laparoscopic hysterectomy operations compared to abdominal or vaginal hysterectomies. Obesity, endometriosis, pelvic adhesions, history of previous surgery, enlarged uterus, and intraoperative hemorrhage are some of the risk factors identified for ureteral injury. Intraoperative cystoscopy and postoperative urinary ultrasonography can be used in the diagnosis of early ureteral injury. Management of ureteral injury differs according to the extent, type, and localization of the injury. In evaluating the ureteral injury, early diagnosis and early repair in appropriate patients are essential in morbidity and medicolegal

Impact of paternal age on intracytoplasmic sperm injection cycle results

Background: The purpose of this study is to compare the impacts of the paternal age of patients included in the intracytoplasmic sperm injection-embryo transfer cycle administered with long protocol. Methods: The patients administered with long agonist protocol, who were primary infertile and had normal over reserves, were divided into two groups based on their sperm concentration. The patients with sperm concentration of over 15 million/ml were defined as group 1, while those with sperm concentration below 15 million/ml were defined as group 2.Results: 602 patients, 302 of whom were in group 1 and 300 of whom were in group 2, enrolled in this study. With regard to treatment results, the implantation rates and clinical pregnancy rates were significantly higher in group 1. In an assessment made to determine if the advanced male age had any impact on the clinical pregnancy rates, it was determined that there was a significant decrease in the clinical pregnancy rates only in group 2. When the patients in group 2 were divided and compared into two patient subgroups, i.e. those below 37 years old and over 37 years old, higher number of mature oocytes, embryos was obtained at a lower dose of recombinant follicular stimulant hormone (r-FSH) in the younger patient subgroup, which significantly increased the clinical pregnancy rates with implementation rates.Conclusions: While the pregnancy and implantation rates significantly decreased by advanced paternal age in oligospermic patients administered with ICSI, the abortus rates increased

Psoriasis and 5HT-R2C Gene Polymorphism: Association between Clinical, Demographic and Therapeutic Parameters in the Turkish Population

We aimed to investigate the relationship between single nucleotide polymorphism (SNP) in the promoter region of the 5-HT-R2C gene and stress-related disease psoriasis in the Turkish population. The putative association between the 5-HTR2C variant (rs6318 Cys23Ser allele) and patients with psoriasis was investigated. 100 patients with psoriasis and 100 age-sex matched, unrelated healthy subjects representing the control group were included in the study. The PCR-RFLP method was used for genotyping the 5-HTR2C variation. There was no statistically difference in terms of genotype distributions and allele frequencies between the control subjects and patients with psoriasis (P=0.360 and P=0.439, respectively). The comparison between the presence and absence of the 5-HTR2C gene rs6318 G allele within the determined clinical subsets resulted in a significant difference with regard to treatment methodology only when conventional therapy and one or more medical therapy was compared (P=0.021). This study is the first clinical study to investigate the association between 5-HTR2C polymorphism and psoriasis. The role of the 5-HTR2C gene should be examined with more parameters in a larger case series

Psoriasis and 5HT-R2C Gene Polymorphism: Association between Clinical, Demographic and Therapeutic Parameters in the Turkish Population

We aimed to investigate the relationship between single nucleotide polymorphism (SNP) in the promoter region of the 5-HT-R2C gene and stress-related disease psoriasis in the Turkish population. The putative association between the 5-HTR2C variant (rs6318 Cys23Ser allele) and patients with psoriasis was investigated. 100 patients with psoriasis and 100 age-sex matched, unrelated healthy subjects representing the control group were included in the study. The PCR-RFLP method was used for genotyping the 5-HTR2C variation. There was no statistically difference in terms of genotype distributions and allele frequencies between the control subjects and patients with psoriasis (P=0.360 and P=0.439, respectively). The comparison between the presence and absence of the 5-HTR2C gene rs6318 G allele within the determined clinical subsets resulted in a significant difference with regard to treatment methodology only when conventional therapy and one or more medical therapy was compared (P=0.021). This study is the first clinical study to investigate the association between 5-HTR2C polymorphism and psoriasis. The role of the 5-HTR2C gene should be examined with more parameters in a larger case series

Recurrent hydatidiform moles: detection of a new mutation in the NLRP7 gene in the family

Hydatidiform moles are the most common type of gestational trophoblastic neoplasia. Hyperproliferative vesicular trophoblasts and imperfect fetal development are abnormal pregnancies, and recurrent hydatidiform moles are rare. Mutations in NLRP7 are responsible for recurrent hydatidiform mole. Genetic heterogeneity has been demonstrated in patients with the NLRP7 mutation. This study presents our case with gravida 11, parity 0, histopathologically diagnosed with six hydatidiform moles and five missed abortion histories at age 35. Karyotype analyses of the unrelated couple were normal. A genetic examination revealed a novel mutation of the NLRP7 gene in the patient, his brother, and his parents. Detecting a new NLRP7 mutation in recurrent hydatidiform moles cases provides further evidence for the predetermined role of NLRP7 mutations in the pathophysiology of recurrent moles hydatidiform. Based on our findings, we hope to contribute to the literature by expanding the spectrum of recurrent pregnancy loss associated with NLRP7 mutations in patients

Development and management of ovarian hyperstimulation syndrome in spontaneous singleton pregnancy

Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening complications of ovulation induction. However, rarely, OHSS can develop spontaneously during pregnancy without induction of ovulation. It has been shown in the literature that some diseases such as polycystic ovary syndrome (PCOS), hypothyroidism, and pituitary adenoma may accompany spontaneous OHSS. Spontaneous OHSS should be included in the differential diagnosis in first-trimester pregnancies with nausea, vomiting, and acute abdomen. The focus should be on preventing possible complications and initiating early treatment immediately after diagnosis

Hormetic effects of cerium, lanthanum and their combination at sub-micromolar concentrations in sea urchin sperm

Rare earth elements (REEs) cerium and lanthanum and their combination were tested across a concentration range, from toxic (10-4 to 10-5 M) to lower concentrations (10-6 to 10-8 M) for their effects on sea urchin (Sphaerechinus granularis) sperm. A significantly decreased fertilization rate (FR) was found for sperm exposed to 10-5 M Ce, La and their combination, opposed to a significant increase of FR following 10-7 and 10-8 M REE sperm exposure. The offspring of REE-exposed sperm showed significantly increased developmental defects following sperm exposure to 10-5 M REEs vs. untreated controls, while sperm exposure to 10-7 and 10-8 M REEs resulted in significantly decreased rates of developmental defects

Assessment of the requisites of microbiology based infectious disease training under the pressure of consultation needs

<p>Abstract</p> <p>Background</p> <p>Training of infectious disease (ID) specialists is structured on classical clinical microbiology training in Turkey and ID specialists work as clinical microbiologists at the same time. Hence, this study aimed to determine the clinical skills and knowledge required by clinical microbiologists.</p> <p>Methods</p> <p>A cross-sectional study was carried out between June 1, 2010 and September 15, 2010 in 32 ID departments in Turkey. Only patients hospitalized and followed up in the ID departments between January-June 2010 who required consultation with other disciplines were included.</p> <p>Results</p> <p>A total of 605 patients undergoing 1343 consultations were included, with pulmonology, neurology, cardiology, gastroenterology, nephrology, dermatology, haematology, and endocrinology being the most frequent consultation specialties. The consultation patterns were quite similar and were not affected by either the nature of infections or the critical clinical status of ID patients.</p> <p>Conclusions</p> <p>The results of our study show that certain internal medicine subdisciplines such as pulmonology, neurology and dermatology appear to be the principal clinical requisites in the training of ID specialists, rather than internal medicine as a whole.</p

Wage Determinants and Wage Inequalities - Case of Construction Engineers in Turkey

WOS: 000460160100004Unfair wage policies that fail to meet the needs of employees have been cited to be one of the most important reasons for high turnover rates of construction professionals. Despite, little research has been conducted related to the determinants of a fair wage, and industry-wide wage policies. Hence, a questionnaire survey was held in 2016 with 305 company/human resource managers and 410 construction engineers working in the Turkish construction industry, which is one of the largest in the world, to determine wage policies of the companies. Findings of the questionnaire survey are discussed within the frame of the literature findings related to the prerequisites of a fair wage. Wages of respondents are compared to the legal minimum wage requirements. Effects of some compensable variables like the level of education, experience, seniority in the company, foreign language skills, computer skills, the complexity of the project, the location of the project and the size of the company on the wage rates are examined by using Multinomial Logistic Regression Analysis and Self Organizing Maps. Lorenz Curves and Gini Coefficients are used to represent and analyze the wage distribution of the respondents. Multinational comparisons are presented where possible. The findings of the current research present a benchmark for further research related to the prevailing wages, wage inequalities, and the wage policies, not only for Turkish construction industry but also for the construction industry worldwide.TUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); Cukurova University, Scientific Research Project Funding (CU BAP) [FBA-2016-5779]The first author of this study has been supported by TUBITAK (The Scientific and Technological Research Council of Turkey) with post graduate scholarship. The first author would like to express his thanks to TUBITAK for this support.; The authors would like to thank to Cukurova University, Scientific Research Project Funding (CU BAP) for their financial support [Project number: FBA-2016-5779]